01
Preclinical therapeutics companies
(Series A–B, 10–50 people)
WhoDiscovery-stage biotech with a lead program and a mechanistic thesis, but no in-house computational biology group.
TriggerTarget selection, IND-enabling decisions, a data package for the next raise, or a new scientific hire asking why the program believes what it believes.
PainA handful of causal assumptions carry the whole program. They were inherited from the founding literature, and nobody has re-examined them since the seed round.
What we deliverEvery core assumption adjudicated—Grounded, Direction-Contested, Refuted, or Supported-by-Similarity-Only—with the evidence counts behind each verdict and a resolution experiment for every contested claim.
02
Longevity and aging biotechnology
WhoCompanies working on cellular senescence, senolytics, partial reprogramming, metabolic aging, or geroprotective interventions.
TriggerA mechanism drawn from a fast-moving, contested literature where the direction of an effect flips between contexts.
PainAging biology has an unusually high rate of paralog confounding and sign disagreement. GDF11 and GDF8/myostatin share a receptor, share antagonists, and cross-react in assays—a rejuvenation thesis staked on one of them is exposed until an isoform-specific reagent separates them.
What we deliverPer-claim adjudication with the contradiction held rather than averaged away, plus the isoform- or context-resolving experiment.
03
Fibrosis, inflammation and immunology programs
WhoCompanies targeting IPF and organ fibrosis, autoimmune disease, and inflammatory disease.
TriggerPathway-level bets where a signalling node is pleiotropic and its sign is context-dependent.
PainThe same pathway is protective in one tissue and pathogenic in another, and a program inherits a direction from a paper run in a different context.
What we deliverDirection-resolved mechanism mapping, with contested signs surfaced as typed contradictions rather than smoothed into a confident summary.